Cleviprex® (clevidipine butyrate): Efficacy of Cleviprex

Efficacy of Cleviprex®

Rapid On, Rapid Off: A Predictable Performance

Cleviprex has a rapid onset and offset of BP-lowering effects for a predictable pharmacologic response, and an ultrashort half-life of approximately 1 minute provides rapid-acting control. Cleviprex demonstrates a dose-dependent BP-lowering response. The onset of effect is seen within 2 to 4 minutes after infusion, and full recovery of BP is achieved 5 to 15 minutes after the infusion is stopped in most patients.¹

Fast On, Fast Off for a Predictable Pharmacologic Response

Graphic illustration adapted from Prescribing Information.

IMPORTANT SAFETY INFORMATION

Cleviprex is intended for intravenous use. Titrate drug depending on the response of the individual patient to achieve the desired blood pressure reduction. Monitor blood pressure and heart rate continually during infusion, and then until vital signs are stable. Patients who receive prolonged Cleviprex infusions and are not transitioned to other antihypertensive therapies should be monitored for the possibility of rebound hypertension for at least 8 hours after the infusion is stopped.

Cleviprex is contraindicated in patients with allergies to soybeans, soy products, eggs, or egg products; defective lipid metabolism such as pathologic hyperlipemia, lipoid nephrosis, or acute pancreatitis if it is accompanied by hyperlipidemia; and in patients with severe aortic stenosis.

Hypotension and reflex tachycardia are potential consequences of rapid upward titration of Cleviprex. Dihydropyridine calcium channel blockers can produce negative inotropic effects and exacerbate heart failure. Monitor heart failure patients carefully. Cleviprex gives no protection against the effects of abrupt beta-blocker withdrawal.

Most common adverse reactions (> 2%) are headache, nausea, and vomiting.

Cleviprex should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Maintain aseptic technique while handling Cleviprex. Cleviprex contains phospholipids and can support microbial growth. Do not use if contamination is suspected. Once the stopper is punctured, use and discard within 4 hours.